Bioperm AB assists pharmaceutical companies in performing studies in man with administration of drugs at predetermined locations in the whole gastrointestinal canal. Thus, studies of local bioavailability, metabolism, active transport, and interactions in the small bowel as well as in the colon may be undertaken. For this purpose, Bioperm has developed a local intubation method via a thin tube and a capsule (in the attached X-ray picture positioned in the ascending colon) for administration of substances in solution or in solid form, e.g. as pellets. A large number of studies have shown the method to be well tolerated by human subjects.